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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2A
All Species:
24.85
Human Site:
S459
Identified Species:
42.05
UniProt:
Q9BY44
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BY44
NP_114414.2
585
64990
S459
R
N
K
P
I
T
N
S
K
L
H
E
E
E
P
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001108004
580
64436
S454
R
N
K
P
I
T
N
S
K
L
H
E
E
E
P
Dog
Lupus familis
XP_534306
585
65159
S459
R
N
K
P
I
T
N
S
K
L
H
E
E
E
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8BJW6
581
64385
S459
R
N
K
P
V
T
N
S
K
L
H
E
E
E
P
Rat
Rattus norvegicus
NP_001102809
541
60196
L440
H
P
S
S
D
K
P
L
S
K
T
A
L
K
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507598
493
54394
A392
D
K
P
L
S
K
T
A
L
K
N
Q
R
K
H
Chicken
Gallus gallus
Q5ZKC1
586
64485
S459
R
N
K
P
V
T
S
S
K
L
H
E
D
E
P
Frog
Xenopus laevis
Q7ZY11
582
64798
Y461
R
N
K
P
V
S
S
Y
K
L
H
E
D
E
P
Zebra Danio
Brachydanio rerio
Q4QRJ7
580
64206
S458
R
N
K
P
Q
T
A
S
S
K
L
H
E
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VNX8
638
70052
N475
R
L
L
K
E
G
K
N
P
E
K
Y
L
P
Q
Honey Bee
Apis mellifera
XP_625143
577
65273
K458
R
G
E
T
I
S
F
K
L
R
D
D
E
M
F
Nematode Worm
Caenorhab. elegans
Q19052
570
64001
A463
P
A
G
A
V
R
Q
A
G
A
Y
I
P
P
H
Sea Urchin
Strong. purpuratus
XP_001186352
299
33040
I197
F
N
P
Q
G
T
I
I
A
L
G
G
F
A
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53235
642
71286
H478
N
K
S
E
L
Q
I
H
S
S
V
Q
E
Y
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.4
96
N.A.
92.8
82.5
N.A.
74.5
84.4
74.8
69.5
N.A.
39
43.9
35.7
29.2
Protein Similarity:
100
N.A.
98.2
98.2
N.A.
95.5
87
N.A.
79.4
91.6
86.5
81.5
N.A.
56.5
61.3
54.8
40
P-Site Identity:
100
N.A.
100
100
N.A.
93.3
0
N.A.
0
80
66.6
53.3
N.A.
6.6
20
0
20
P-Site Similarity:
100
N.A.
100
100
N.A.
100
6.6
N.A.
26.6
100
93.3
53.3
N.A.
13.3
40
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
45.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
0
0
8
15
8
8
0
8
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
8
0
0
0
0
0
8
8
15
0
0
% D
% Glu:
0
0
8
8
8
0
0
0
0
8
0
43
50
50
8
% E
% Phe:
8
0
0
0
0
0
8
0
0
0
0
0
8
0
8
% F
% Gly:
0
8
8
0
8
8
0
0
8
0
8
8
0
0
0
% G
% His:
8
0
0
0
0
0
0
8
0
0
43
8
0
0
15
% H
% Ile:
0
0
0
0
29
0
15
8
0
0
0
8
0
0
8
% I
% Lys:
0
15
50
8
0
15
8
8
43
22
8
0
0
15
0
% K
% Leu:
0
8
8
8
8
0
0
8
15
50
8
0
15
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
8
58
0
0
0
0
29
8
0
0
8
0
0
0
15
% N
% Pro:
8
8
15
50
0
0
8
0
8
0
0
0
8
15
43
% P
% Gln:
0
0
0
8
8
8
8
0
0
0
0
15
0
0
8
% Q
% Arg:
65
0
0
0
0
8
0
0
0
8
0
0
8
0
0
% R
% Ser:
0
0
15
8
8
15
15
43
22
8
0
0
0
0
0
% S
% Thr:
0
0
0
8
0
50
8
0
0
0
8
0
0
0
0
% T
% Val:
0
0
0
0
29
0
0
0
0
0
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
8
8
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _